KMID : 0371320100780040219
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Journal of the Korean Surgical Society 2010 Volume.78 No. 4 p.219 ~ p.224
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Clinicopathologic Characteristics of Anal Cancer
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Kim Soo-Hong
Kim Hyung Jin Lee Jae-Im Kye Bong-Hyun Lee In-Kyu Lee Yoon-Suk Kang Won-Kyung Kim Jun-Gi Oh Seung-Tack
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Abstract
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Purpose: This study was performed to evaluate clinicopathologic features in anal canal carcinoma.
Methods: Among the 43 patients who were diagnosed with anal cancer at Kangnam St. Mary¡¯s Hospital, from June 1990 to June 2008, 31 patients were analyzed retrospectively. Concurrent chemoradiotherapy was performed on twenty-one patients with anal cancer. Chemotherapy with 5-FU/mitomycin and radiotherapy were started at the same time. An external beam radiation dose to the primary lesion and pelvis was modified from 4,500 to 6,000 cGy.
Results: Among the 31 patients with anal cancer, the dominant histologic type was squamous cell carcinoma (n=25), followed by adenocarcinoma (n=6). Twenty-nine (93.5%) of these cancers were located in the anal canal and 2 (6.5%) in the anal margin. Among the 25 patients with squamous cell carcinoma, 20 cases were treated by concurrent chemoradiotherapy. The 5-year survival rate among squamous cell carcinoma cases was 83.3% for the concurrent chemoradiation group and 50.0% for the no concurrent chemoradiation group, which was statistically significant (P=0.05). Among the squamous cell carcinoma patients, there was no significant difference in survival rates between concurrent chemoradiation group (n=17) and concurrent chemoradiation with surgical resection group (n=8) (87.5% vs 68.8%; P=0.596).
Conclusion: In the squamous cell carcinoma treatment, concurrent chemoradiation therapy can offer better outcomes.
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KEYWORD
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Anal cancer, Concurrent chemoradiation therapy
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